Offering luggage storage, the 3-star Ca' Dei Leoni Hotel Venice lies in Cannaregio, which is probably Venice's most authentic district, just 1.8 km from the ornate covered 16th-century stone footbridge "Rialto Bridge" and about 900 metres from Constitution Bridge. While staying at this Venice hotel, a safety deposit box and 24-hour security service are available for guests to use.

The centre of Venice can be reached in 5 minutes' walk of the hotel, and such cultural venues as Museo Leonardo da Vinci are approximately 5 minutes' drive away. You can find Ca' Pesaro International Gallery of Modern Art, which is a great place to explore the area, within a few blocks of the Ca' Dei Leoni Venice. Also, Giardini Papadopoli is situated merely 0.8 km away. There is the cathedral church "Basilica di San Marco" nearly a 10-minute ride away, and Piazzale Roma bus station is within 10 minutes' walk of the accommodation. Marco Polo airport is a 15-minute drive away, while Venezia Santa Lucia railway station is in close proximity to Ca' Dei Leoni Hotel.

This Venice hotel welcomes guests to 8 rooms fitted with air conditioning as well as Wi-Fi and an LCD TV set. They are appointed with a writing desk, and also feature a mini-bar, tea and coffee making equipment. A bidet, a separate toilet, and a shower, along with a hairdryer and towels, are offered in the bathrooms. A kitchen with a microwave, an electric kettle, and refrigerators are available in an apartment.

Situated just 150 metres from the Ca' Dei Leoni, the seafood restaurant Ai Tre Archi offers a European menu.