Located only 450 metres from the Rialto Bridge, the 3-star San Marco Secret 4343 Hotel Venice offers access to tourist attractions throughout Venice.

The centre of Venice can be reached in 15 minutes' walk of the guest house, and such cultural venues as the Jewish Museum of Venice are merely 1.6 km away. The Bridge of Sighs is 800 m from this Venice hotel, which is also situated a few steps from the Teatro La Fenice. The Constitution Bridge is just 1.8 km from the San Marco Secret 4343 Venice. Marco Polo airport is a 20-minute drive away, while Venezia Santa Lucia railway station is within 20 minutes' walk of the accommodation.

Some rooms include a balcony and a dressing room featuring an iron with ironing board and soundproof walls, along with wireless internet and a flat-screen television. Some bathrooms have a bidet, along with a dryer and complimentary toiletries.

At Dal Moro's Fresh Pasta to Go, situated not far from San Marco Secret 4343 Hotel, you can taste Italian cuisine.