Nestled in Santa Croce, which is the only sestiere of Venice where cars and buses are allowed to move around before having to stop due to the lack of roads and abundance of canals, Piccin House Hotel Venice is about 20 minutes' walk from the public Ca' Rezzonico Museum.

The Constitution Bridge is not very far away, while Venezia Santa Lucia train station is a short way from the guest house. Sights, a mere 1.6 km from this Venice hotel, include the ornate footbridge "Rialto Bridge". Guests might as well enjoy proximity to Giardino Malipiero, situated just 14 minutes' walk away. There is the Patriarchal Cathedral Basilica di San Marco 2.7 km away, and Piazzale Roma bus station is in proximity to the Piccin House Venice.

Italian cuisine is served at Bacaro Quebrado that lies 100 metres away.